As the Marvel Cinematic Universe continues to expand, the differences between the films, the Netflix series and the cable shows continue to grow. According to Captain America: The Winter Soldier star Anthony Mackie, who plays Falcon, this is exactly why a crossover would never work.
Different universes, different worlds, different companies, different designs. [Marvel Studios president] Kevin Feige is very specific about how he wants the Marvel Universe to be seen in the film world. It wouldnt work. It wouldnt work at all, Mackie said at Wizard World Cleveland, as reported by ScreenGeek.
Of course, that doesnt mean the shows are completely sanitized of any MCU references. Both the Netflix and ABC shows frequently reference MCU characters like Captain America and Thor, as well as the invasion of New York during The Avengers. Most notably, Agents of S.H.I.E.L.D. was deeply impacted by the revelation that Hydra had infiltrated the organization, as per the events of Captain America: The Winter Solider. That event has influenced the direction of the show through the shows fourth season, which revisits the idea of a world run by Hydra.
Conversely, the MCUs films never make mention of the events of the television shows. As Mackie points out in his quote, Feige controls the world of the films, where Jeph Loeb runs Marvel TV, a separate entity. While all of these properties take place in the MCU, they are controlled by different studios: the films by Marvel Studios, and the television shows by Marvel TV. As such, the chances of a true crossover between all these properties is slim, if not impossible. Marvel TV occasionally builds franchises around characters who originated in the films like S.H.I.E.L.D.s Coulson or Agent Carters Peggy but youd be hard-pressed to find the shows impacting the films in a crucial way.
No Infinity War for you!